Actos Lawsuit Advice
Actos Lawsuit : Cancer, including bladder cancer, develops because of changes in the DNA of a normal cell. DNA can be damaged by chemical exposures such as cigarette smoke, industrial chemicals, chemotherapy, and so forth. (See Questions 10 and 11.) Environmental exposures such as these are called risk factors. Risk factors do not exactly cause bladder cancer. Not everyone who smokes will get bladder cancer. However, as a group, the risk is elevated relative to people who do not smoke. Exposures such as these increase the likelihood of DNA becoming damaged. When the specific DNA that controls a cell’s growth is damaged, the cell then has the potential to become cancerous. The hallmark of cancer is overgrowth of cells, causing compression of surrounding tissues or destruction of the tissues.
Some risk factors, such as your genes, cannot be changed. Many more, however, can be changed. Cigarette smoking is the biggest risk factor for getting bladder cancer. If you are a smoker, the most important thing you can do is to quit today. If someone you live with smokes, encourage that person to quit also. Question 10 discusses what are called modifiable risk factors. These are the lifestyle and environmental things that you can change to decrease your chances of getting bladder cancer. Look over this list carefully, and do everything you can to change your lifestyle now to help protect your future and your family’s future.
As we alluded to previously here, not everyone has the same risk of developing cancer. By studying the characteristics of patients who have bladder cancer, researchers have been able to identify groups of people who seem to develop the disease more often than others. These groups of people each have some risk factor that they are born with, things that predispose them to cancer no matter how carefully they live their lives. In fact, our genetic makeup probably plays the biggest role in determining who among us is destined to get cancer.
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Different races have different risks of bladder cancer. Caucasian (white) Americans are twice as likely to develop transitional cell cancer (the most common type of bladder cancer), as are African Americans. For the more rare type of bladder cancer, called squamous cell cancer, however, the reverse is true; African Americans are twice as likely to develop squamous cell cancer of the bladder than are white individuals. Of all the different races, Caucasians seem to have the highest rate of bladder cancer. Men are almost three times more likely to develop cancer than women. This is before taking into consideration modifiable risk factors such as smoking and workplace exposures to chemicals. More than 65% of bladder cancer occurs in patients who are older than 65. Patients in this age group are also more likely to develop more aggressive tumor types than are the younger bladder cancer patients.
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As you may remember from the prior discussion, cancer develops only after something goes haywire in the regulatory process of cell growth or cell death. Several different genes normally accomplish this regulation. In a normal, healthy cell, these genes promote growth or suppress growth or can even signal a cell to destroy itself in an appropriate situation. For a cell to become cancerous, many of these genes must be altered or destroyed simultaneously. Nature has even supplied our cells with other genes that are able to repair damaged genes. These “repairmen” genes are known as tumor suppressor genes. Their job is to repair damaged DNA when possible or to drive a damaged cell to destroy itself.
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